Here is the setup via Starz for the start of the second season (as well as a trailer):
After nearly losing his career, his family and his mind, Mayor Tom Kane’s (Kelsey Grammer) grip on Chicago is as powerful as ever. With high doses of medication, he’s able to beat back the physical symptoms of his debilitating brain disease, but it comes at a cost. Kane is left with intense and uncontrollable neurological side effects.
Despite the delusions, Kane breaks ground on the O’Hare Airport expansion and looks toward his next endeavor – protecting and repairing his legacy. With the astute counsel of new aides Mona Fredricks (Sanaa Lathan) and Ian Todd (Jonathan Groff), he plans to remove and rebuild a long forgotten housing project, now home to gang activity and rampant corruption. Committed to his unorthodox agenda, Kane prepares to cut out the cancers within the political machine he helped build.
Fully aware of Kane’s illness, his wife Meredith (Connie Nielsen) finds herself questioning who holds the key to preserving her position of power. While their daughter, Emma (Hannah Ware), who is a product of their loveless, political marriage, battles her own destructive demons. Without his longtime advisors Ezra Stone (Martin Donovan) and Kitty O’Neil (Kathleen Robertson), and his political protégé Ben Zajac (Jeff Hephner), the odds continue to stack against him.
As corrupt heads roll and his list of enemies grows, Kane's virtuous actions begin to erode the very foundation of power he's worked a lifetime to build. In order to maintain it, Kane must govern as he always has—ruthlessly.
Last season was brutal on the characters and audience as we watched the slow spiral downward of a once great mayor, taking out innocent and guilty alike in his wake. And Kelsey Grammer is amazing to watch as he takes on the world in what becomes a one man, winner takes all show. Grammer certainly deserved his 2012 Golden Globe as best actor in a television series for his work on Boss. Oddly, the show has not been nominated for any Emmys this year, though Grammer has done well in the past. Earlier this week on the Tonight Show, Grammer attributed the Emmy snub to his being a republican. I think he was kidding, but it was not clear. He needs to show a little more Mayor Kane in his approach to life and simply tough it out. He is part of a great show, and the critics will soon be eating crow.
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